I've had an interesting suggestion put to me for the use of Alfresco in a high volume compliance proposition for the FSI market.
Where high volume means somewhere in the order of 100,000+ new items generated per day, each around 50Kb in size.
I've seen Gavin and Paul's posts that indicate that Alfresco is regularly tested with 500,000 items and has once successfully scaled to 4 million items without problems (http://forums.alfresco.com/viewtopic.php?t=344). However, are there any clear technical reasons (or obvious burdens) to prevent reaching the type of scale I've mentioned above?